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首页> 外文OA文献 >Degenerate 87-base-pair tandem repeats create hydrophilic/hydrophobic alternating domains in human mucin peptides mapped to 11p15.
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Degenerate 87-base-pair tandem repeats create hydrophilic/hydrophobic alternating domains in human mucin peptides mapped to 11p15.

机译：简并的87个碱基对的串联重复在映射至11p15的人粘蛋白肽中产生亲水/疏水交替结构域。

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A human tracheobronchial lambda gt 11 cDNA library was screened using antiserum prepared against the deglycosylated protein backbone of human tracheobronchial mucins. Two cDNAs, designated JER 28 and 57, obtained from this immunoscreening, were used to isolate two other cDNA clones, JUL 7 and JUL 10, from a human tracheobronchial lambda gt 10 cDNA library. These four clones (561, 1830, 1631 and 991 bp), which mapped to chromosome 11p15, were all found to contain degenerate 87-base-pair tandem repeats which encode non-repetitive peptides. Numerous deletions or insertions in an otherwise virtually perfect 87-base-pair tandem repeat create many shifts in reading frame which completely destroy the repetitive peptide structure. The peptide is composed of alternate hydrophobic and hydrophilic domains which probably differ in the extent to which they are glycosylated. The mRNAs are expressed both in the respiratory and in the digestive tracts. These human mucin probes may be important in assessing the abnormal mucins associated with inflammatory diseases or carcinoma from human mucosae.
机译：使用针对人气管支气管粘蛋白的去糖基化蛋白骨架制备的抗血清筛选人气管支气管λgt11 cDNA文库。从该免疫筛选获得的两个cDNA，分别称为JER 28和57，被用于从人气管支气管λgt10 cDNA文库中分离出另外两个cDNA克隆，JUL 7和JUL 10。发现映射到染色体11p15的这四个克隆（561、1830、1631和991 bp）都包含简并的87个碱基对的串联重复序列，这些重复序列编码非重复性肽段。否则的话，实际上是完美的87个碱基对的串联重复序列中的大量缺失或插入会导致阅读框发生许多移位，从而完全破坏了重复的肽结构。该肽由交替的疏水和亲水结构域组成，它们的糖基化程度可能不同。 mRNA在呼吸道和消化道中均表达。这些人类粘蛋白探针在评估与人类粘膜炎性疾病或癌相关的异常粘蛋白方面可能很重要。

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